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Scott HL, Nguyen VP, Alves DS, Davis FL, Booth KR, Bryner J, Barrera FN. The negative charge of the membrane has opposite effects on the membrane entry and exit of pH-low insertion peptide. Biochemistry, 2015, 54, 1709-1712.

Kyrychenko A, Vasquez-Montes V, Ulmschneider MB, Ladokhin AS. Lipid headgroups modulate membrane insertion of pHLIP peptide. Biophys J, 2015, 108, 791-794.

Brown MC, Yakubu RA, Taylor J, Halsey CM, Xiong J, Jiji RD, Cooley JW. Bilayer surface association of the pHLIP peptide promotes extensive backbone desolvation and helically-constrained structures. Biophys Chem, 2014, 187-188, 1-6.

Kong CP, Cui YL, Zhang JL, Zheng QC, Zhang HX. Mechanism of a pH-induced peptide inserting into a POPC bilayer: a molecular dynamic study. Curr Pharm Biotechnol, 2014, 15, 814-822.

Deng Y, Qian Z, Luo Y, Zhang Y, Mu Y, Wei G. Membrane binding and insertion of a pHLIP peptide studied by all-atom molecular dynamics simulations. Int J Mol Sci, 2013, 14, 14532-14549.

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Barrera FN, Weerakkody D, Anderson M, Andreev OA, Reshetnyak YK, Engelman DM. Roles of carboxyl groups in the transmembrane insertion of peptides. J Mol Biol, 2011, 413, 359-371.

Fu L, Liu J, Yan EC. Chiral sum frequency generation spectroscopy for characterizing protein secondary structures at interfaces. J Am Chem Soc, 2011, 133, 8094-8097.

Guo L, Gai F. Heterogeneous diffusion of a membrane-bound pHLIP peptide. Biophys J, 2010, 98, 2914-2922.

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Andreev OA, Karabadzhak AG, Weerakkody D, Andreev GO, Engelman DM, Reshetnyak YK. pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path. Proc Natl Acad Sci U S A, 2010, 107, 4081-4086.

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Tang J, Gai F. Dissecting the membrane binding and insertion kinetics of a pHLIP peptide. Biochemistry, 2008, 47, 8250-8252.

Zoonens M, Reshetnyak YK, Engelman DM. Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors. Biophys J, 2008, 95, 225-235.

Reshetnyak YK, Segala M, Andreev OA, Engelman DM. A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. Biophys J, 2007, 93, 2363-2372.

Hunt JF, Rath P, Rothschild KJ, Engelman DM. Spontaneous, pH-dependent membrane insertion of a transbilayer alpha-helix. Biochemistry, 1997, 36, 15177-15192.

Ying Z, Shi M, Gong W, Chen Y, Jiang G. g(E)-pHLIP promote virus immunity to destroy cervical cancer cell. Eur J Med Res. 2026, In press.

He P, Wu X, Li M, Liu K, Chen Y, Zhang Q, Cheng H, Li Y, Yang S. Decoupling Half-Process Assisted Mitochondrial Transplantation via Self-Stripping pHLIP Boosts Macrophages Reprogramming for Inflammation Resolution. Small. 2025, e07970.

Yang G, Wang S, Wang Y, Zheng H, Du M, Wang Z, Chen Z, Chang C, Yu G. Preparation, expression, and anti-cancer effects of the novel fusion protein rONC-T7-pHLIP. Appl Microbiol Biotechnol. 2025, 109(1), 207.

Cai J, Wang S, Zhou A, Zhang D, Zhou F, Zhao Z. Membrane Protein-Binding and Membrane-Inserting Chimeras for Cancer Therapy. Bioconjug Chem., 2025, 36 (10), 2116-2123

Li Y, Zhou S, Fu W, Li X, Chen T, Le H, Xu Y, Tang Y, Mi P, Gao H, Wu Q, Gong C. A versatile immunomodulated nanoCRISPR converter augments the susceptibility and visibility of tumors to the immune system. Proc Natl Acad Sci U S A. 2025, 122 (29), e2415100122.

Zhang YT, Fu X, Ting Lim JJ, Zhang SX. Engraftment of a surrogate antigen onto tumor cell surface via pHLIP peptide to universally target CAR-T cell therapy to solid tumors. Cancer Lett. 2025, 608, 217319.

Zheng H, Wang M, Feng J, Zhang Y, Wu H, Zhang M, Xiao H, Qiao C, Wang J, Luo L, Li X, Feng J, Zheng Y, Wang Y, Sheng D, Chen G. Improved acid-driven inhibition of effector T cell function by a pHLIP variant-conjugated PD-L1. Sci Rep. 2025, 15 (1), 13422.

Mo M, Wang F, Zhang H, Zhang Y, Yang C, Shang J, Zhu Z. Membrane-Bounded Intracellular E3 Ubiquitin Ligase-Targeting Chimeras (MembTACs) for Targeted Membrane Protein Degradation. Angew Chem Int Ed Engl. 2025, e202501857.

Zhang L, Feng Q, Zheng C, Li Y, Ge X, Jin T, Hu G, Tan Z, Wang J, Xu J, Jiang L, Wang D, Ying Z, Zhao X, Cheng K, Li Q, Ge M. Antigen-Targeting Inserted Nanomicelles Guide Pre-Existing Immunity to Kill Head and Neck Cancer. Adv Sci (Weinh). 2025 Mar 17:e2410629.

Kim H, Woo CG, Son SM, Lee YP, Kim HK, Yang Y, Kwon J, Lee KH, Lee HC, Lee OJ, Han HS. Targeted Suppression of CEACAM6 via pHLIP-Delivered RNAs in Pancreatic Ductal Adenocarcinoma. Medicina (Kaunas). 2025, 61 (4), 598.

Yurkevicz AM, Liu Y, Katz SG, Glazer PM. Tumor-specific antigen delivery for T-cell therapy via a pH-sensitive peptide conjugate. Mol Cancer Ther. 2024, 24(1), 105-117

Knepper LE, Ankrom ET, Thévenin D. Enhancing Anti-Cancer Immune Response by Acidosis-Sensitive Nanobody Display. J Membr Biol. 2024, 257 (5-6), 391-401

Zhang YT, Fu X, Ting Lim JJ, Zhang SX. Engraftment of a Surrogate Antigen onto Tumor Cell Surface via pHLIP Peptide to Universally Target CAR-T Cell Therapy to Solid Tumors. Cancer Lett. 2024 Nov 1:217319.

Ankrom ET, Dalesandro B, Pires MM, Thévenin D. Selective Recruitment of Antibodies to Cancer Cells and Immune Cell-mediated Killing via In Situ Click Chemistry. Chem Med Chem. 2024, e202400356.

Shi T, Sun M, Tuerhong S, Li M, Wang J, Wang Y, Zheng Q, Zou L, Lu C, Sun Z, Zou Z, Shao J, Du J, Li R, Liu B, Meng F. Acidity-targeting transition-aided universal chimeric antigen receptor T-cell (ATT-CAR-T) therapy for the treatment of solid tumors. Biomaterials. 2024, 309, 122607.

Feng J, Zheng H, Zhang Y, Wu H, Wang M, Sun Y, Zhang M, Xiao H, Qiao C, Wang J, Luo L, Li X, Feng J, Shi Y, Zheng Y, Wang Y, Sheng D, Chen G. pHLIP-fused PD-L1 engages avelumab to elicit NK cytotoxicity under acidic conditions. Heliyon. 2024, 10 (9), e30551.

Kelly JJ, Ankrom ET, Newkirk SE, Thévenin D, Pires MM. Targeted acidosis mediated delivery of antigenic MHC-binding peptides. Front Immunol. 2024, 15, 1337973.

Deskeuvre M, Lan J, Messens J, Riant O, Feron O, Frédérick R. A novel approach to pH-Responsive targeted cancer Therapy: Inhibition of FaDu cancer cell proliferation with a pH low insertion Peptide-Conjugated DGAT1 inhibitor. Int J Pharm. 2024, 657, 124132.

Moshnikova A, DuPont M, Iraca M, Klumpp C, Visca H, Allababidi D, Pelzer P, Engelman DM, Andreev OA, Reshetnyak YK. Targeted intracellular delivery of dimeric STINGa by two pHLIP peptides for treatment of solid tumors. Front Pharmacol., 2024, 15, 1346756.

DuPont M, Klumpp C, Iraca M, Allababidi D, Visca H, Engelman DM, Andreev OA, Moshnikova A, Reshetnyak YK. pHLIP targeted intracellular delivery of calicheamicin. Int J Pharm. 2024, Feb 28, 123954.

Ding GB, Cao H, Zhu C, Chen F, Ye J, Li BC, Yang P, Stauber RH, Qiao M, Li Z. Biosynthesized tumor acidity and MMP dual-responsive plant toxin gelonin for robust cancer therapy. Biomater Sci. 2023, 12, 346-360.

Matsui T, Toda Y, Sato H, Itagaki R, Konishi K, Moshnikova A, Andreev OA, Hosogi S, Reshetnyak YK, Ashihara E. Targeting acidic pre-metastatic niche in lungs by pH low insertion peptide and its utility for anti-metastatic therapy. Front Oncol. 2023, 13, 1258442.

Dhuri K, Duran T, Chaudhuri B, Slack FJ, Vikram A, Glazer PM, Bahal R. Head- to-head comparison of in vitro and in vivo efficacy of pHLIP- conjugated anti-seed gamma peptide nucleic acids. Cell Rep Phys Sci. 2023, 4 (10), 101584.

Frolova AY, Pakhomov AA, Kakuev DL, Sungurova AS, Dremina AA, Mamontova ED, Deyev SM, Martynov VI. Hybrid protein-peptide system for the selective pH- dependent binding and photodynamic ablation of cancer cells. J Photochem Photobiol B. 2023, 249, 112803.

Wachira FW, Githirwa DC, McPartlon T, Nazarenko V, Gonzales JJC, Gazura MM, Leen C, Clary HR, Alston C, Klees LM, Yao L, An M. D-to-E and T19V Variants of the pH-Low Insertion Peptide and Their Doxorubicin Conjugates Interact with Membrane at Higher pH Ranges Than WT. Biochemistry. 2023, 62, 2997-3011.

Chu T, Cao B, Wang P, Li B, Ren J, Nie G, Wei J, Li S. Tumor-Targeted Delivery of IL-2 by Fusing with a pH Low Insertion Peptide for Antitumor Immunotherapy. Bioconjug Chem. 2023, 34, 1894-1901.

Son SM, Yun J, Kim DW, Jung YS, Han SB, Lee YH, Han HS, Woo CG, Lee HC, Lee OJ. MicroRNA 29a therapy for CEACAM6-expressing lung adenocarcinoma. BMC Cancer. 2023, 23, 843.

Li S, Wang Y, Jiang H, Bai Y, Chen T, Chen M, Ma M, Yang S, Wu Y, Shi C, Wang F, Chen Y. Display of CCL21 on cancer cell membrane through genetic modification using a pH low insertion peptide. Int J Biol Macromol. 2023, 240, 124324.

Wu H, Zheng L, Ling N, Zheng L, Du Y, Zhang Q, Liu Y, Tan W, Qiu L. Chemically Synthetic Membrane Receptors Establish Cells with Artificial Sense- and-Respond Signaling Pathways. J Am Chem Soc. 2023, 145, 2315-2321.

DuPont M, Visca H, Moshnikova A, Engelman DM, Reshetnyak YK, Andreev OA. Tumor Treatment by pHLIP-Targeted Antigen Delivery. Front. Bioeng. Biotechnol. 2023, 10, 1082290.

Moshnikova A, DuPont M, Visca H, Engelman DM, Andreev OA, Reshetnyak YK. Eradication of tumors and development of anti-cancer immunity using STINGa targeted by pHLIP. Front Oncol. 2022, 12, 1023959.

Moshnikova A, Golijanin B, Amin A, Doyle J, Kott O, Gershman B, DuPont M, Li Y, Lu X, Engelman DM, Andreev OA, Reshetnyak YK and Golijanin D Targeting bladder urothelial carcinoma with pHLIP-ICG and inhibition of urothelial cancer cell proliferation by pHLIP-amanitin. Front. Urol., 2022, 2, 868919

Gayle S, Paradis T, Jones K, Vasquez J, Paralkar VM. Antigen-independent tumor targeting by CBX-12 (alphalex^™-exatecan) induces long-term antitumor immunity. Immunotherapy. 2022, 14, 1467-1480.

Shi D, Zhang H, Zhang H, Li L, Li S, Zhao Y, Zheng C, Nie G, Yang X. The synergistic blood-vessel-embolization of coagulation fusion protein with temperature sensitive nanogels in interventional therapies on hepatocellular carcinoma. Chem. Engineering. J., 2022, 443, 134357.

Zhang M, Xi Y, Chen H, Hai W, Li B. In Vivo Distribution and Therapeutic Efficacy of Radioiodine-Labeled pH-Low Insertion Peptide Variant 3 in a Mouse Model of Breast Cancer. Mol Imaging. 2022, 2022, 7456365.

Deskeuvre M, Lan J, Dierge E, Messens J, Riant O, Corbet C, Feron O, Frédérick R. Targeting cancer cells in acidosis with conjugates between the carnitine palmitoyltransferase 1 inhibitor etomoxir and pH (low) Insertion Peptides. Int J Pharm. 2022, 624, 122041

Zhang X, Rotllan N, Canfrán-Duque A, Sun J, Toczek J, Moshnikova A, Malik S, Price NL, Araldi E, Zhong W, Sadeghi MM, Andreev OA, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C. Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression. Circ Res. 2022, 131, 77-90.

Ding GB, Zhu C, Wang Q, Cao H, Li BC, Yang P, Stauber RH, Nie G, Li Z. Molecularly engineered tumor acidity-responsive plant toxin gelonin for safe and efficient cancer therapy. Bioact Mater. 2022, 18, 42-55.

Sikorski EL, Wehr J, Ferraro NJ, Rizzo SM, Pires MM, Thévenin D. Selective Display of a Chemoattractant Agonist on Cancer Cells Activates the Formyl Peptide Receptor 1 on Immune Cells. Chembiochem. 2022, Feb 23, e202100521.

Mendoza C, Mizrachi D. Using the Power of Junctional Adhesion Molecules Combined with the Target of CAR-T to Inhibit Cancer Proliferation, Metastasis and Eradicate Tumors. Biomedicines. 2022, 10, 381.

Sun Y, Hu L, Yang P, Zhang M, Wang X, Xiao H, Qiao C, Wang J, Luo L, Feng J, Zheng Y, Wang Y, Shi Y, Chen G. pH Low Insertion Peptide-Modified Programmed Cell Death-Ligand 1 Potently Suppresses T-Cell Activation Under Acidic Condition. Front Immunol. 2021, 12, 794226.

Gayle S, Aiello R, Leelatian N, Beckta JM, Bechtold J, Bourassa P, Csengery J, Maguire RJ, Marshall D, Sundaram RK, Doorn JV, Jones K, Moore H, Lopresti-Morrow L, Paradis T, Tylaska L, Zhang Q, Visca H, Reshetnyak YK, Andreev OA, Engelman DM, Glazer PM, Bindra RS, Paralkar VM, Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity, NAR Cancer, 2021, 3, 1-13.

Chen YH, Yu MM, Wang ZG. Inhibition of MDA-MB-231 cell proliferation by pHLIP(Var7)-P1AP and SPECT imaging of MDA-MB-231 breast cancer-bearing nude mice using 125I-pHLIP(Var7)-P1AP. Nuklearmedizin. 2021, 60, 240-248.

Wehr J, Sikorski EL, Bloch E, Feigman MS, Ferraro NJ, Baybutt TR, Snook AE, Pires MM, Thévenin D. pH-Dependent Grafting of Cancer Cells with Antigenic Epitopes Promotes Selective Antibody-Mediated Cytotoxicity. J Med Chem, 2020, 63, 3713-3722.

Svoronos AA, Bahal R, Pereira MC, Barrera FN, Deacon JC, Bosenberg M, DiMaio D, Glazer PM, Engelman DM. Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules Using a pH-Low Insertion Peptide. Mol Pharm, 2020, 17, 461-471.

Kaplan AR, Pham H, Liu Y, Oyaghire S, Bahal R, Engelman DM, Glazer PM. Ku80-targeted pH-sensitive peptide-PNA conjugates are tumor selective and sensitize cancer cells to ionizing radiation. Mol Cancer Res. 2020, 18, 873-882

Yu M, Chen Y, Wang Z, Ding X. pHLIP(Var7)-P1AP suppresses tumor cell proliferation in MDA-MB-231 triple-negative breast cancer by targeting protease activated receptor 1. Breast Cancer Res Treat, 2020, 180, 379-384.

Sahraei M, Chaube B, Liu Y, Sun J, Kaplan A, Price NL, Ding W, Oyaghire S, García-Milian R, Mehta S, Reshetnyak YK, Bahal R, Fiorina P, Glazer PM, Rimm DL, Fernández-Hernando C, Suárez Y. Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response. J Clin Invest, 2019, e127125.

Price NL, Miguel V, Ding W, Singh AK, Malik S, Rotllan N, Moshnikova A, Toczek J, Zeiss C, Sadeghi MM, Arias N, Baldán Á, Andreev OA, Rodríguez-Puyol D, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C, Lamas S. Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis. JCI Insight, 2019, 4, e131102.

Ding L, Zhang C, Liu Z, Huang Q, Zhang Y, Li S, Nie G, Tang H, Wang Y. Metabonomic investigation of biological effects of a new vessel target protein tTF-pHLIP in a mouse model. J Proteome Res, 2019, 19, 238-247.

Son SM, Yun J, Lee SH, Han HS, Lim YH, Woo CG, Lee HC, Song HG, Gu YM, Lee HJ, Lee OJ. Therapeutic Effect of pHLIP-mediated CEACAM6 Gene Silencing in Lung Adenocarcinoma. Sci Rep, 2019, 9, 11607.

Joyce S, Nour AM. Blocking transmembrane219 protein signaling inhibits autophagy and restores normal cell death. PLoS One, 2019, 14, e0218091.

Ji T, Lang J, Ning B, Qi F, Wang H, Zhang Y, Zhao R, Yang X, Zhang L, Li W, Shi X, Qin Z, Zhao Y, Nie G. Enhanced Natural Killer Cell Immunotherapy by Rationally Assembling Fc Fragments of Antibodies onto Tumor Membranes. Adv Mater, 2018, 31, e1804395.

Gerhart J, Thévenin AF, Bloch E, King KE, Thévenin D. Inhibiting Epidermal Growth Factor Receptor Dimerization and Signaling Through Targeted Delivery of a Juxtamembrane Domain Peptide Mimic. ACS Chem Biol, 2018, 13, 2623-2632.

Zhao Z, Li C, Song B, Sun J, Fu X, Yang F, Wang H, Yan B. pH low insertion peptide mediated cell division cycle-associated protein 1 -siRNA transportation for prostatic cancer therapy targeted to the tumor microenvironment. Biochem Biophys Res Commun, 2018, 503, 1761-1767.

Wyatt LC, Moshnikova A, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK. Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors. Proc Natl Acad Sci U S A, 2018, 115, E2811-E2818.

Burns KE, Delehanty JB. Cellular delivery of doxorubicin mediated by disulfide reduction of a peptide-dendrimer bioconjugate. Int J Pharm, 2018, 545, 64-73.

Ding GB, Sun J, Wu G, Li B, Yang P, Li Z, Nie G. Robust anticancer efficacy of a biologically synthesized tumor acidity-responsive and autophagy-inducing functional Beclin 1. ACS Appl Mater Interfaces, 2018, 10, 5227-5239.

Özeş AR, Wang Y, Zong X, Fang F, Pilrose J, Nephew KP. Therapeutic targeting using tumor specific peptides inhibits long non-coding RNA HOTAIR activity in ovarian and breast cancer. Sci Rep, 2017, 7, 894.

Burns KE, Hensley H, Robinson MK, Thévenin D. Therapeutic efficacy of a family of pHLIP-MMAF conjugates in cancer cells and mouse models. Mol Pharm, 2017, 14, 415-422.

Burns KE, McCleerey TP, Thévenin D. pH-Selective cytotoxicity of pHLIP-antimicrobial peptide conjugates. Sci Rep, 2016, 6, 28465.

Song Q, Chuan X, Chen B, He B, Zhang H, Dai W, Wang X, Zhang Q. A smart tumor targeting peptide-drug conjugate, pHLIP-SS-DOX: synthesis and cellular uptake on MCF-7 and MCF-7/Adr cells. Drug Deliv, 2016, 23, 1734-1746.

Burns KE, Thévenin D. Down-regulation of PAR1 activity with a pHLIP-based allosteric antagonist induces cancer cell death. Biochem J, 2015, 472, 287-295.

Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature, 2015, 518, 107-110.

Li S, Tian Y, Zhao Y, Zhang Y, Su S, Wang J, Wu M, Shi Q, Anderson GJ, Thomsen J, Zhao R, Ji T, Wang J, Nie G. pHLIP-mediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth. Oncotarget, 2015, 6, 23523-23532.

Burns KE, Robinson MK, Thévenin D. Inhibition of cancer cell proliferation and breast tumor targeting of pHLIP-monomethyl auristatin E conjugates. Mol Pharm, 2015, 12, 1250-1258.

Moshnikova A, Moshnikova V, Andreev OA, Reshetnyak YK. Antiproliferative effect of pHLIP-amanitin. Biochemistry, 2013, 52, 1171-1178.

Wijesinghe D, Engelman DM, Andreev OA, Reshetnyak YK. Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide., Biochemistry, 2011, 50, 10215-10222.

An M, Wijesinghe D, Andreev OA, Reshetnyak YK, Engelman DM. pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation. Proc Natl Acad Sci U S A, 2010, 107, 20246-20250.

Thévenin D, An M, Engelman DM. pHLIP-mediated translocation of membrane-impermeable molecules into cells. Chem Biol, 2009, 16, 754-762.

Reshetnyak YK, Andreev OA, Lehnert U, Engelman DM. Translocation of molecules by pH-dependent insertion of a transmembrane helix. Proc Natl Acad Sci U S A, 2006, 103, 6460-6465.

Chirizzi C, Maffezzini M, Mosca N, Balestri A, Montis C, Acerbi F, Beccalli M, Gori A, Grisoli M, Pellegatta S, Baldelli Bombelli F. A fluorescein-tagged pH-low insertion peptide (pHLIP) for glioblastoma imaging: Lipid membrane interaction and cancer cell targeting. Colloids Surf B Biointerfaces. 2026, 260, 115398.

Yu X, Dong J, Bian H, Wang F, Wei Y, Ji M, Zong Z, Fu H, Liu D. Rationally Engineering a pH-Low Insertion Peptide Variant Probe for High-Sensitivity Imaging of Early Tumors. ACS Appl Mater Interfaces. 2025, 17 (26), 37489-37499.

Ye Q, Jo J, Wang CY, Oh H, Zhan J, Choy TJ, Kim KI, D'Alessandro A, Reshetnyak YK, Jung SY, Chen Z, Marrelli SP, Lee HK. Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation. Cell Rep. 2024, 43 (5), 114193.

Chen Y, Song S, Sun Y, Wu F, Yang G, Wang Z, Yu M. Small animal PET imaging with the ⁶⁸Ga-labeled pH (low) insertion peptide-like peptide YJL-4 in a triple-negative breast cancer mouse model. EJNMMI Radiopharm Chem. 2024, 9 (1), 33.

Mc Larney BE, Kim M, Roberts S, Skubal M, Hsu HT, Ogirala A, Pratt EC, Pillarsetty NVK, Heller DA, Lewis JS, Grimm J. Ambient Light Resistant Shortwave Infrared Fluorescence Imaging for Preclinical Tumor Delineation via the pH Low- Insertion Peptide Conjugated to Indocyanine Green. J Nucl Med. 2023, 64, 1647-1653.

Zong Z, Liu X, Ye Z, Liu D. A double-switch pHLIP system enables selective enrichment of circulating tumor microenvironment-derived extracellular vesicles. Proc Natl Acad Sci U S A. 2023, 120, e2214912120.

Visca H, DuPont M, Moshnikova A, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK. pHLIP Peptides Target Acidity in Activated Macrophages. Mol Imaging Biol. 2022, 24, 874-885.

Bauer D, Visca H, Weerakkody A, Carter LM, Samuels Z, Kaminsky S, Andreev OA, Reshetnyak YK, Lewis JS. PET Imaging of Acidic Tumor Environment With ⁸⁹Zr-labeled pHLIP Probes. Front Oncol. 2022, 12, 882541.

Chen Y, Su Y, Pang X, Song X, Zhao W, Yu M. Synthesis and Evaluation of Technetium-99m-Labeled pH (Low) Insertion Peptide Variant 7 for Early Diagnosis of MDA-MB-231 Triple-Negative Breast Cancer by Targeting the Tumor Microenvironment. Front Oncol. 2022, 12, 869260.

Hulikova A, Park KC, Loonat AA, Gunadasa-Rohling M, Curtis MK, Chung YJ, Wilson A, Carr CA, Trafford AW, Fournier M, Moshnikova A, Andreev OA, Reshetnyak YK, Riley PR, Smart N, Milne TA, Crump NT, Swietach P. Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart. Basic Res Cardiol. 2022, 117, 17.

Wu F, Chen Y, Li D, Wang Z, Yu M. Synthesis and Evaluation of Radioiodine- Labeled pH (Low) Insertion Peptide Variant 7-Like Peptide as a Noninvasive Tumor Microenvironment Imaging Agent in a Mouse MDA-MB-231 Triple-Negative Breast Cancer Model. Mol Imaging Biol. 2022, 24, 570-579.

Frolova AY, Pakhomov AA, Kakuev DL, Sungurova AS, Deyev SM, Martynov VI. Cancer cells targeting with genetically engineered constructs based on a pH- dependent membrane insertion peptide and fluorescent protein. Biochem Biophys Res Commun. 2022, 612, 141-146.

Wilson AD, Richards MA, Curtis MK, Rohling M, Monterisi S, Loonat AA, Miller J, Ball V, Lewis A, Tyler D, Moshnikova A, Andreev OA, Reshetnyak YK, Carr C, Swietach P. Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH. Cardiovasc Res. 2021, Dec 13, cvab364.

Svoronos AA, Engelman DM. Pharmacokinetic modeling reveals parameters that govern tumor targeting and delivery by a pH-Low Insertion Peptide (pHLIP). Proc Natl Acad Sci U S A. 2021, 118, e2016605118.

Mitrou A, Feng X, Khan A, Yaroslavsky AN. Feasibility of dual-contrast fluorescence imaging of pathological breast tissues. J Biophotonics. 2021 May 19, e202100007.

Chen YH, Yu MM, Wang ZG. Inhibition of MDA-MB-231 cell proliferation by pHLIP(Var7)-P1AP and SPECT imaging of MDA-MB-231 breast cancer-bearing nude mice using 125I-pHLIP(Var7)-P1AP. Nuklearmedizin. 2021, 60, 240-248.

Yu M, Sun Y, Yang G, Wang Z. An Experimental Study on I-pHLIP (Var7) for SPECT/CT Imaging of an MDA-MB-231 Triple- Negative Breast Cancer Mouse Model by Targeting the Tumor Microenvironment. Mol Imaging. 2021, 5565932.

Miska J, Rashidi A, Lee-Chang C, Gao P, Lopez-Rosas A, Zhang P, Burga R, Castro B, Xiao T, Han Y, Hou D, Sampat S, Cordero A, Stoolman JS, Horbinski CM, Burns M, Reshetnyak YK, Chandel NS, Lesniak MS. Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma. Sci Adv. 2021, 7, eabc8929.

Crawford T, Moshnikova A, Roles S, Weerakkody D, DuPont M, Carter LM, Shen J, Engelman DM, Lewis JS, Andreev OA, Reshetnyak YK. pHLIP ICG for delineation of tumors and blood flow during fluorescence-guided surgery. Sci Rep. 2020, 10, 18356.

Wu H, Estrella V, Beatty M, Abrahams D, El-Kenawi A, Russell S, Ibrahim- Hashim A, Longo DL, Reshetnyak YK, Moshnikova A, Andreev OA, Luddy K, Damaghi M, Kodumudi K, Pillai SR, Enriquez-Navas P, Pilon-Thomas S, Swietach P, Gillies RJ. T-cells produce acidic niches in lymph nodes to suppress their own effector functions. Nat Commun. 2020, 11, 4113.

Henry KE, Chaney AM, Nagle VL, Cropper HC, Mozaffari S, Slaybaugh G, Parang K, Andreev O, Reshetnyak YK, James ML, Lewis JS. Demarcation of Sepsis-Induced Peripheral and Central Acidosis with pH-Low Insertion Cyclic (pHLIC) Peptide. J Nucl Med, 2020, 61, 1361-1368.

Pereira PMR, Edwards KJ, Mandleywala K, Carter LM, Escorcia FE, Campesato LF, Cornejo M, Abma L, Mohsen AA, Iacobuzio-Donahue CA, Merghoub T, Lewis JS. iNOS regulates the therapeutic response of pancreatic cancer cells to radiation therapy. Cancer Res, 2020, 80, 1681-1692.

Wei D, Engelman DM, Reshetnyak YK, Andreev OA. Mapping pH at Cancer Cell Surfaces. Mol Imaging Biol, 2019, 21, 1020-1025.

Brito J, Golijanin B, Kott O, Moshnikova A, Mueller-Leonhard C, Gershman B, Andreev OA, Reshetnyak YK, Amin A, Golijanin D. Ex-vivo Imaging of Upper Tract Urothelial Carcinoma Using Novel pH Low Insertion Peptide (Variant 3), a Molecular Imaging Probe. Urology, 2020, 139, 134-140

Rohani N, Hao L, Alexis MS, Joughin BA, Krismer K, Moufarrej MN, Soltis AR,Lauffenburger DA, Yaffe MB, Burge CB, Bhatia SN, Gertler FB. Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes. Cancer Res, 2019, 79, 1952-1966.

Roberts S, Strome A, Choi C, Andreou C, Kossatz S, Brand C, Williams T, Bradbury M, Kircher MF, Reshetnyak YK, Grimm J, Lewis JS, Reiner T. Acid specific dark quencher QC1 pHLIP for multi-spectral optoacoustic diagnoses of breast cancer. Sci Rep, 2019, 9, 8550.

Golijanin J, Amin A, Moshnikova A, Brito JM, Tran TY, Adochite RC, Andreev GO, Crawford T, Engelman DM, Andreev OA, Reshetnyak YK, Golijanin D. Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo. Proc Natl Acad Sci U S A, 2016, 113, 11829-11834.

Adochite RC, Moshnikova A, Golijanin J, Andreev OA, Katenka NV, Reshetnyak YK. Comparative study of tumor targeting and biodistribution of pH (Low) Insertion Peptides (pHLIP® peptides) conjugated with different fluorescent dyes. Mol Imaging Biol, 2016, 18, 686-696.

Anderson M, Moshnikova A, Engelman DM, Reshetnyak YK, Andreev OA. Probe for the measurement of cell surface pH in vivo and ex vivo. Proc Natl Acad Sci U S A, 2016, 113, 8177-8181.

Weerakkody D, Moshnikova A, El-Sayed NS, Adochite RC, Slaybaugh G, Golijanin J, Tiwari RK, Andreev OA, Parang K, Reshetnyak YK. Novel pH-sensitive cyclic peptides. Sci Rep, 2016, 6, 31322.

Demoin DW, Wyatt LC, Edwards KJ, Abdel-Atti D, Sarparanta M, Pourat J, Longo VA, Carlin SD, Engelman DM, Andreev OA, Reshetnyak YK, Viola-Villegas N, Lewis JS. PET imaging of extracellular pH in tumors with (64)Cu- and (18)F-labeled pHLIP peptides: A structure-activity optimization study. Bioconjug Chem, 2016, 27, 2014-2023.

Tapmeier TT, Moshnikova A, Beech J, Allen D, Kinchesh P, Smart S, Harris A, McIntyre A, Engelman DM, Andreev OA, Reshetnyak YK, Muschel RJ. The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A, 2015, 112, 9710-9715.

Cardo L, Thomas SG, Mazharian A, Pikramenou Z, Rappoport JZ, Hannon MJ, Watson SP. Accessible synthetic probes for staining actin inside platelets and megakaryocytes by employing lifeact peptide. Chembiochem, 2015, 16, 1680-1688.

Reshetnyak YK. Imaging tumor acidity: pH-Low Insertion Peptide probe for optoacoustic tomography. Clin Cancer Res, 2015, 21, 4502-4504.

Kimbrough CW, Khanal A, Zeiderman M, Khanal BR, Burton NC, McMasters KM, Vickers SM, Grizzle WE, McNally LR. Targeting acidity in pancreatic adenocarcinoma: multispectral optoacoustic tomography detects pH-Low Insertion Peptide probes in vivo. Clin Cancer Res, 2015, 21, 4576-4585.

Karabadzhak AG, An M, Yao L, Langenbacher R, Moshnikova A, Adochite RC, Andreev OA, Reshetnyak YK, Engelman DM. pHLIP-FIRE, a cell insertion-triggered fluorescent probe for imaging tumors demonstrates targeted cargo delivery in vivo. ACS Chem Biol, 2014, 9, 2545-2553.

Cruz-Monserrate Z, Roland CL, Deng D, Arumugam T, Moshnikova A, Andreev OA, Reshetnyak YK, Logsdon CD. Targeting pancreatic ductal adenocarcinoma acidic microenvironment. Sci Rep, 2014, 4, 4410.

Luo Z, Loja MN, Farwell DG, Luu QC, Donald PJ, Amott D, Truong AQ, Gandour-Edwards R, Nitin N. Widefield optical imaging of changes in uptake of glucose and tissue extracellular pH in head and neck cancer. Cancer Prev Res, 2014, 7, 1035-1044.

Adochite RC, Moshnikova A, Carlin SD, Guerrieri RA, Andreev OA, Lewis JS, Reshetnyak YK. Targeting breast tumors with pH (low) insertion peptides. Mol Pharm, 2014, 11, 2896-2905.

Viola-Villegas NT, Carlin SD, Ackerstaff E, Sevak KK, Divilov V, Serganova I, Kruchevsky N, Anderson M, Blasberg RG, Andreev OA, Engelman DM, Koutcher JA, Reshetnyak YK, Lewis JS. Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer. Proc Natl Acad Sci U S A, 2014, 111, 7254-7259.

Li N, Yin L, Thévenin D, Yamada Y, Limmon G, Chen J, Chow VT, Engelman DM, Engelward BP. Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiol, 2013 8, 257-69.

Loja MN, Luo Z, Greg Farwell D, Luu QC, Donald PJ, Amott D, Truong AQ, Gandour-Edwards RF, Nitin N. Optical molecular imaging detects changes in extracellular pH with the development of head and neck cancer. Int J Cancer, 2013, 132, 1613-1623.

Sosunov EA, Anyukhovsky EP, Sosunov AA, Moshnikova A, Wijesinghe D, Engelman DM, Reshetnyak YK, Andreev OA. pH (low) insertion peptide (pHLIP) targets ischemic myocardium. Proc Natl Acad Sci U S A, 2013, 110, 82-86.

Weerakkody D, Moshnikova A, Thakur MS, Moshnikova V, Daniels J, Engelman DM, Andreev OA, Reshetnyak YK. Family of pH (low) insertion peptides for tumor targeting. Proc Natl Acad Sci U S A, 2013, 110, 5834-5839.

Emmetiere F, Irwin C, Viola-Villegas NT, Longo V, Cheal SM, Zanzonico P, Pillarsetty N, Weber WA, Lewis JS, Reiner T. 18F-labeled-bioorthogonal liposomes for in vivo targeting. Bioconjugate Chem, 2013, 24, 1784–1789.

Macholl S, Morrison MS, Iveson P, Arbo BE, Andreev OA, Reshetnyak YK, Engelman DM, Johannesen E. In vivo pH imaging with (99m)Tc-pHLIP. Mol Imaging Biol, 2012, 14, 725-734.

Daumar P, Wanger-Baumann CA, Pillarsetty N, Fabrizio L, Carlin SD, Andreev OA, Reshetnyak YK, Lewis JS. Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation. Bioconjug Chem, 2012, 23, 1557-1566.

Reshetnyak YK, Yao L, Zheng S, Kuznetsov S, Engelman DM, Andreev OA. Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP. Mol Imaging Biol, 2011, 13, 1146-1156.

Segala J, Engelman DM, Reshetnyak YK, Andreev OA. Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP). Int J Mol Sci, 2009, 10, 3478-3487.

Vavere AL, Biddlecombe GB, Spees WM, Garbow JR, Wijesinghe D, Andreev OA, Engelman DM, Reshetnyak YK, Lewis JS. A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res, 2009, 69, 4510-4516.

Andreev OA, Dupuy AD, Segala M, Sandugu S, Serra DA, Chichester CO, Engelman DM, Reshetnyak YK. Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc Natl Acad Sci U S A, 2007, 104, 7893-7898.

Agarwal H, Singh R, Bynum RC, McNally M, Holter-Chakrabarty J, Jain A, Grizzle WE, McNally LR. pH-Responsive Liposomes for Targeted Detection of Pancreatic Adenocarcinoma Using MSOT. Chem Biomed Imaging. 2025, 3 (11), 732-741.

Liu C, Zhang K, Ge R, Wang W, Liu X, Li X, Hao P, Li H. Boosting mRNA Therapeutics: pHLIP Enhances Endosomal Escape and Gene Expression in Lipid Nanoparticle. Adv Healthc Mater. 2025, e02567.

Hou W, Hong W, Cai S, Guo D, Yan Z, Zhu J, Shen Y, Wan J, Qu X, Zhang W, Zhao R, Xie Z, Chen Z, Jiang T, Lin Y, Jia W, Wang L, Huang Z, Li X, Tang B. RRM2-targeted nanocarrier enhances radiofrequency ablation efficacy in hepatocellular carcinoma through ferroptosis amplification and immune remodeling. Imeta. 2025, 4 (5), e70067.

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Cai S, Huang J, Fan H, Sui Z, Huang C, Deng Y, Jia R, Wang L, Ma K, Guo X, He J, Zhang B, Yu Z. Targeted tumor cell-intrinsic CTRP6 biomimetic codelivery synergistically amplifies ferroptosis and immune activation to boost anti-PD-L1 immunotherapy efficacy in lung cancer. J Nanobiotechnology. 2025, 23 (1), 409.

Zhang L, Feng Q, Zheng C, Li Y, Ge X, Jin T, Hu G, Tan Z, Wang J, Xu J, Jiang L, Wang D, Ying Z, Zhao X, Cheng K, Li Q, Ge M. Antigen-Targeting Inserted Nanomicelles Guide Pre-Existing Immunity to Kill Head and Neck Cancer. Adv Sci (Weinh). 2025, e2410629.

Tong F, Hu H, Xu Y, Zhou Y, Xie R, Lei T, Du Y, Yang W, He S, Huang Y, Gong T, Gao H. Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor-associated macrophages. Acta Pharm Sin B. 2023, 13, 3471-3488.

Sharma KS, Raju M S, Phapale S, Valvi SK, Dubey AK, Goswami D, Ray D, De A, Phadnis PP, Aswal VK, Vatsa R, Sarma HD. Multimodal Applications of Zinc Gallate-Based Persistent Luminescent Nanoparticles in Cancer Treatment: Tumor Margining, Diagnosis, and Boron Neutron Capture Therapy. ACS Appl Bio Mater. 2022, 5, 3134-3145.

Wei X, Zhao H, Huang G, Liu J, He W, Huang Q. ES-MION-Based Dual-Modality PET/MRI Probes for Acidic Tumor Microenvironment Imaging. ACS Omega. 2022, 7, 3442-3451.

Hao L, Rohani N, Zhao RT, Pulver EM, Mak H, Kelada OJ, Ko H, Fleming HE, Gertler FB, Bhatia SN. Microenvironment-triggered multimodal precision diagnostics. Nat Mater. 2021, 20, 1440-1448.

MacCuaig WM, Fouts BL, McNally MW, Grizzle WE, Chuong P, Samykutty A, Mukherjee P, Li M, Jasinski JB, Behkam B, McNally LR. Active Targeting Significantly Outperforms Nanoparticle Size in Facilitating Tumor-Specific Uptake in Orthotopic Pancreatic Cancer. ACS Appl. Mater. Interfaces 2021, 13, 49614-49630.

Demin AM, Pershina AG, Minin AS, Brikunova OY, Murzakaev AM, Perekucha NA, Romashchenko AV, Shevelev OB, Uimin MA, Byzov IV, Malkeyeva D, Kiseleva E, Efimova LV, Vtorushin SV, Ogorodova LM, Krasnov VP. Smart Design of a pH- Responsive System Based on pHLIP-Modified Magnetite Nanoparticles for Tumor MRI. ACS Appl Mater Interfaces. 2021, 13, 36800-36815.

Sharma KS, Raju SM, Goswami D, De A, Phadnis PP, Vatsa RK. pH-(Low)-Insertion Peptide-Assisted Detection and Diagnosis of Cancer Using Zinc Gallate-Based Persistent Luminescence Nanoparticles, ACS Appl. Bio Mater. 2021, 4, 742–751.

Chen Y, Wu T, Liu S, Pan W, Li N, Tang B. Cell membrane-anchoring covalent organic framework nanosheets for single-laser-triggered synergistic tumor therapy. Chem Commun (Camb). 2021, 57, 11685-11688.

Li Q, Zhang J, Li J, Ye H, Li M, Hou W, Li H, Wang Z. Glutathione-Activated NO-/ROS-Generation Nanoparticles to Modulate the Tumor Hypoxic Microenvironment for Enhancing the Effect of HIFU-Combined Chemotherapy. ACS Appl Mater Interfaces. 2021, 13, 26808-26823.

Liu W, Deacon J, Yan H, Sun B, Liu Y, Hegan D, Li Q, Coman D, Parent M, Hyder F, Roberts K, Nath R, Tillement O, Engelman D, Glazer P. Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image- guided nanoparticle-enhanced radiation therapy. Transl Oncol. 2020, 13, 100839.

Schuerle S, Furubayashi M, Soleimany AP, Gwisai T, Huang W, Voigt C, Bhatia SN. Genetic Encoding of Targeted Magnetic Resonance Imaging Contrast Agents for Tumor Imaging. ACS Synth Biol, 2020, 9, 392-401.

Pershina AG, Brikunova OY, Demin AM, Abakumov MA, Vaneev AN, Naumenko VA, Erofeev AS, Gorelkin PV, Nizamov TR, Muslimov AR, Timin AS, Malkeyeva D, Kiseleva E, Vtorushin SV, Larionova IV, Gereng EA, Minin AS, Murzakaev AM, Krasnov VP, Majouga AG, Ogorodova LM. Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticles. Nanomedicine. 2020, 32, 102317.

Sah B, Wu J, Vanasse A, Pandey NK, Chudal L, Huang Z, Song W, Yu H, Ma L, Chen W, Antosh MP. Effects of Nanoparticle Size and Radiation Energy on Copper- Cysteamine Nanoparticles for X-ray Induced Photodynamic Therapy. Nanomaterials (Basel). 2020, 10, 1087.

Wang YQ, Ji MY, Wang C. Endoplasmic reticulum-targeted glutathione and pH dual responsive vitamin lipid nanovesicles for tocopheryl DM1 delivery and cancer therapy. Int J Pharm, 2020, 582, 119331.

Han H, Hou Y, Chen X, Zhang P, Kang M, Jin Q, Ji J, Gao M. Metformin-Induced Stromal Depletion to Enhance the Penetration of Gemcitabine-Loaded Magnetic Nanoparticles for Pancreatic Cancer Targeted Therapy.J Am Chem Soc, 2020, 142, 4944-4954.

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Sah B, Shrestha S, Wu J, Vanasse A, Cooper LN, Antosh M. Gold Nanoparticles Enhance Radiation Therapy at Low Concentrations, and Remain in Tumors for Days. J Biomed Nanotechnol. 2019, 15, 1960-1967

Shrestha S, Wu J, Sah B, Vanasse A, Cooper LN, Ma L, Li G, Zheng H, Chen W, Antosh MP. X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors. Proc Natl Acad Sci U S A. 2019, 116, 16823-16828.

Zhang HJ, Zhao X, Chen LJ, Yang CX, Yan XP. pH-Driven Targeting Nanoprobe with Dual-Responsive Drug Release for Persistent Luminescence Imaging and Chemotherapy of Tumor. Anal Chem, 2019, 92, 1179-1188.

Di Z, Zhao J, Chu H, Xue W, Zhao Y, Li L. An Acidic-Microenvironment-Driven DNA Nanomachine Enables Specific ATP Imaging in the Extracellular Milieu of Tumor. Adv Mater, 2019, e1901885.

Pershina AG, Ya Brikunova O, Demin AM, Shevelev OB, Razumov IA, Zavjalov EL,Malkeyeva D, Kiseleva E, Krakhmal’ NV, Vtorushin SV, Yarnykh VL, Ivanov VV, Pleshko RI, Krasnov VP, Ogorodova LM. pH-triggered delivery of magnetic nanoparticles depends on tumor volume. Nanomedicine, 2019, 23, 102086.

Huang W, Zhao H, Wan J, Zhou Y, Xu Q, Zhao Y, Yang X, Gan L. pH- and photothermal-driven multistage delivery nanoplatform for overcoming cancer drug resistance. Theranostics, 2019, 9, 3825-3839.

Zhang K, Lin H, Mao J, Luo X, Wei R, Su Z, Zhou B, Li D, Gao J, Shan H. An extracellular pH-driven targeted multifunctional manganese arsenite delivery system for tumor imaging and therapy. Biomater Sci, 2019, 7, 2480-2490.

Rinaldi F, Hanieh PN, Del Favero E, Rondelli V, Brocca P, Pereira MC, Andreev OA, Reshetnyak YK, Marianecci C, Carafa M. Decoration of Nanovesicles with pH (Low) Insertion Peptide (pHLIP) for Targeted Delivery. Nanoscale Res Lett, 2018, 13, 391.

Zhang Y, Ji W, He L, Chen Y, Ding X, Sun Y, Hu S, Yang H, Huang W, Zhang Y, Liu F, Xia L. E. coli Nissle 1917-derived minicells for targeted delivery of chemotherapeutic drug to hypoxic regions for cancer therapy. Theranostics, 2018, 8, 1690-1705.

Qiu L, Valente M, Dolen Y, Jäger E, Beest MT, Zheng L, Figdor CG, Verdoes M. Endolysosomal-escape nanovaccines through adjuvant-induced tumor antigen assembly for enhanced effector CD8(+) T cell activation. Small, 2018, 14, e1703539.

Liao G, Wang L, Yu W. Application of novel targeted molecular imaging probes in the early diagnosis of upper urinary tract epithelial carcinoma. Oncol Lett, 2018, 16, 6349-6354.

Ai F, Wang N, Zhang X, Sun T, Zhu Q, Kong W, Wang F, Zhu G. An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy. Nanoscale, 2018, 10, 4432-4441.

Zhang Y, Dang M, Tian Y, Zhu Y, Liu W, Tian W, Su Y, Ni Q, Xu C, Lu N, Tao J, Li Y, Zhao S, Zhao Y, Yang Z, Sun L, Teng Z, Lu G. Tumor acidic microenvironment targeted drug delivery based on pHLIP modified mesoporous organosilica nanoparticles. ACS Appl Mater Interfaces, 2017, 9, 30543-30552.

Daniels JL, Crawford TM, Andreev OA, Reshetnyak YK. Synthesis and characterization of pHLIP® coated gold nanoparticles. Biochem Biophys Rep, 2017, 10, 62-69.

Pereira MC, Pianella M, Wei D, Moshnikova A, Marianecci C, Carafa M, Andreev OA, Reshetnyak YK. pH-Sensitive pHLIP® coated niosomes. Mol Membr Biol, 2017, 33, 51-63.

Tian Y, Zhang Y, Teng Z, Tian W, Luo S, Kong X, Su X, Tang Y, Wang S, Lu G. pH-Dependent transmembrane activity of peptide-functionalized gold nanostars for computed tomography/photoacoustic imaging and photothermal therapy. ACS Appl Mater Interfaces, 2017, 9, 2114-2122.

Wei Y, Liao R, Mahmood AA, Xu H, Zhou Q. pH-responsive pHLIP (pH low insertion peptide) nanoclusters of superparamagnetic iron oxide nanoparticles as a tumor-selective MRI contrast agent. Acta Biomater, 2017, 55, 194-203.

Yu M, Guo F, Wang J, Tan F, Li N. A pH-Driven and photoresponsive nanocarrier: Remotely-controlled by near-infrared light for stepwise antitumor treatment. Biomaterials, 2016, 79, 25-35.

Zeiderman MR, Morgan DE, Christein JD, Grizzle WE, McMasters KM, McNally LR. Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography. ACS Biomater Sci Eng, 2016, 2, 1108-1120.

Janic B, Bhuiyan MP, Ewing JR, Ali MM. pH-Dependent cellular internalization of paramagnetic nanoparticle. ACS Sens, 2016, 1, 975-978.

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